Serotonin and serotonin reuptake inhibitors alter placental aromatase

Selective Serotonin Reuptake Inhibitors

It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...

Selective serotonin reuptake inhibitors.

Serotonin Noradrenaline Reuptake Inhibitors (SNRIs)

Antidepressants that block the reuptake of serotonin (5-HT) and noradrenaline (NA) are called 5-HT and NA reuptake inhibitors (SNRIs). SNRIs are agents that show “dual action” on 5-HT and NA. These drugs bind the 5-HT transporters (SERT) and NA transporters (NAT) similar to tricyclic antidepressants (TCAs). However, SNRIs differ from TCAs in that SNRIs do not exert much affinity for other recep...

Serotonin reuptake inhibitors and heart defects.

The paper by Bérard et al. [1] ostensibly is a review of epidemilogy methods. It is also a platform for Dr. Bérard to advance the pinions to which she has testified in birth defect lawsuits against anufacturers of serotonin reuptake inhibitors. These opinions are ot generally accepted; neither are they acceptable. The authors egin their paper using serotonin reuptake inhibitors as an examle of ...

Serotonin reuptake inhibitors, Raynaud's phenomenon and erythromelalgia.

(Letter to the Editor) SIR, We read with great interest the report by Coleiro et al. [1] describing a pilot study on the tolerability and efficiency of fluoxetine for the treatment of Raynaud's phenomenon. This study confirmed previous case reports suggesting the usefulness of selective serotonin reuptake inhibitors (SSRIs) in the management of Raynaud's phenomenon [2, 3]. Here we describe for ...